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Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
(2018)
The simultaneous inhibition of polo-like kinase 1 (PLK1) and BRD4 bromodomain by a single molecule
could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and BRD4 are ...
Proximate Composition, Mineral Element Profile and Antioxidant Properties of the Edible Kenyan Mushroom, Auricularia polytricha
(2022-07)
The indigenous Kenyan Auricularia polytricha is a known delicacy to the communities residing around
Kakamega forest in Western Kenya. The objective of the present study was to carry out proximate analysis,
determine ...
Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation
(2016-10)
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential ...
A review on chemistry of some species of genus Vepris (Rutaceae family)
(2014)
This review presents the current known phytochemical constituents of the genus Vepris. The genus is a rich source of alkaloids and limonoids most of which possess the 3, 4-methylenedioxy moieties. They are frequently used ...
Efficacy of Mangrove (Rhizophora Mucronata) Roots Powder in Adsorption of Lead (II) Ions from Aqueous Solutions: Equilibrium and Kinetics Studies
(2016-08)
The removal of Pb (II) ions by adsorption onto mangrove roots adsorbent was investigated in this
present paper. The removal of lead ions from aqueous solutions was investigated in batch mode which involved
the study of ...
Isolation and Identification of Bioactive Constituents from Stem Barks of Illicium difengpi
(2014)
Objective To isolate and identify bioactive constituents from the stem barks of Illicium difengpi. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, recrystallization, and ...
Chemical Constituents in Extracts from Leaves of Lantana trifolia and Their In Vitro Anti-oxidative Activity
(2014)
Objective To isolate, purify, and analyze the anti-oxidants from the leaves of Lantana trifolia. Methods The anti-oxidative activities of the crude extracts from liquid-liquid extraction of L. trifolia leaves were assayed ...
[3 + 2] Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones
(2019-04-01)
A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of ...
Development of Dimethylisoxazole-Attached Imidazo[1,2‑a]pyridines as Potent and Selective CBP/P300 Inhibitors
(2021)
The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodo main extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET ...
One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates†
(2017)
A method for the catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates is develo ped through a one-pot synthesis involving denitrogenation of azide, benzisoxazole formation, aza-Diels–
Alder ...