Browsing by Author "Erickson, Jon"

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[3 + 2] Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones

Muthengi, Alex; Erickson, Jon; Muriph, Rachel E.; Zhang, Wei (2019-04-01)

A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of ...
Development of Dimethylisoxazole-Attached Imidazo[1,2‑a]pyridines as Potent and Selective CBP/P300 Inhibitors

Muthengi, Alex; Wimalasena, Virangika K.; Yosief, Hailemichael O.; Bikowitz, Melissa J.; Sigua, Logan H.; Wang, Tingjian; Li, Deyao; Zhang, Wei; Qi, Jun; Schönbrunn, Ernst; Amaro, Rommie E.; Erickson, Jon; Liu, Shuai; Dhawan, Gagan; Gaieb, Zied (2021)

The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodo main extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET ...