Browsing by Author "Zhang, Xiaofeng"
Now showing items 1-3 of 3
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[3+2] Cycloaddition-based one-pot synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold
Zhang, Xiaofeng; Legris, Marc; Muthengi, Alex; Zhang, Wei (2017-01)Three-component [3+2] cycloaddition followed by reduction and lactamization has been developed as a one-pot methodology for diastereoselective synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold. -
Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines†
Muthengi, Alex; Zhang, Xiaofeng; Dhawan, Gagan; Zhang, Wensheng; Corsinia, Francesca; Zhang, Wei (2018-06)A two-step method for the (3 + 2) cycloaddition of azomethine ylides followed by a double SN2 substi tution-based (5 + n) annulation is introduced for the modular synthesis of dihydrobenzoxazine, tetra hydrobenzoxazepine ... -
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
Liu, Shuai; Yosief, Hailemichael O.†; Dai, Lingling; Huang, He; Dhawan, Gagan; Zhang, Xiaofeng; Muthengi, Alex; Roberts, Justin; Buckley, Dennis L.; Perry, Jennifer A.; Wu, Lei; Bradner, James E.; Qi, Jun; Zhang, Wei (2018)The simultaneous inhibition of polo-like kinase 1 (PLK1) and BRD4 bromodomain by a single molecule could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and BRD4 are ...