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[3 + 2] Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones
(2019-04-01)
A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of ...
Development of Dimethylisoxazole-Attached Imidazo[1,2‑a]pyridines as Potent and Selective CBP/P300 Inhibitors
(2021)
The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodo main extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET ...