• Login
    View Item 
    •   Repository Home
    • Research Journal Articles
    • Department of Natural Resource Management
    • View Item
    •   Repository Home
    • Research Journal Articles
    • Department of Natural Resource Management
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Exploring the Dynamic Role of Gamma-Delta T Cells in Clinical Pathology: A Systematic Review of Current Knowledge and Future Perspectives

    Thumbnail
    View/Open
    Exploring the Dynamic Role of Gamma-Delta T Cells in Clinical Pathology....pdf (308.7Kb)
    Date
    2023
    Author
    Asamba, Micah N
    Wepukhulu, Miriam
    Stevens, Momo G.
    Metadata
    Show full item record
    Abstract
    Gamma-delta [γδ] T cells are a significant subset of T cells with ability to recognize many antigens without the guidance of major histocompatibility complex (MHC) molecules. A lot of studies have been conducted on them ever since they were discovered 36 years ago. Advances have been made about their structure and function. Thus, there is a need for an up-to-date review about their significance as well as their roles in Multiple Sclerosis. The study aimed to provide an up-to-date knowledge concerning gamma delta T cells in pathogenesis of Multiple Sclerosis (MS). A systematic review methodology was used to scope information from recent studies about gamma delta T cells. The review was carried out in PubMed database and it followed the PRISMA guidelines. The computerized review yielded 60 peer-reviewed articles published between 2011 and 2020. The results showed that gamma delta cells play a critical role in protection against infections and the fight against malignant cells. Most of the reviewed studies highlighted recent advances in research. It was noted that the subset of T cells plays a role in pathogenesis of MS. Several studies have highlighted the protective and detrimental effects of γδ T cells. On the one hand, the cells contribute to the pathogenesis of MS, while, on the other hand, they also help in immunoregulation. However, there is a dearth of literature on their specific role and their mechanism of action. Therefore, further studies are needed about γδ T cells in both human and animal model studies. Based on the findings of the reviewed studies, there is great promise in the use of γδ T cells for MS immunotherapy.
    URI
    http://repository.tharaka.ac.ke/xmlui/handle/1/4326
    Collections
    • Department of Natural Resource Management [50]

    Tharaka University copyright © 2020  Repository
    Contact Us | Send Feedback
    Designed by
    TUN Library
     

    TUN
     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Tharaka University copyright © 2020  Repository
    Contact Us | Send Feedback
    Designed by
    TUN Library
     

    TUN